[Applescript] A no-response reminder for Mail

Is there a way to make a script remind me to follow up a mail that has not gotten any response? I have a script that creates a reminder from a mail, which works great but this system will be cluttered if every important mail is put in there.

Apparently this is not very easy but I would love to be able to click on a mail press a shortcut for a script and then choose the amount of time the person has to respond before I am alerted.

Thanks in advance:)