My heading explains my problem. I have added they section of my script with the issue at hand. The document 1 template will save into the filepath and then close correctly, but once Quark tries to open the filepath the error pops up. Any help with this would be great. Thanks
if (exists document 1) is true then
set workpath to ("" & (path to current user folder)) & "Desktop:" as text
tell application "QuarkXPress"
set filepath to workpath & "file.qxp"
save document 1 in filepath version 80
close document 1 saving no
open filepath use doc prefs yes remap fonts no with reflow
end tell
end if